
The afflicted suffer with pain at the base of the thumb which is aggravated by thumb use
1 in 10 people have some degree of thumb base arthritis with many choosing to put up with the discomfort because of limited treatment options.
5% of the world's population have severe symptoms. This increases to over 30% for women over the age of 55.
There is in excess of 200,000 surgical procedures carried out each year in the EU and US combined for severe thumb base arthritis.
The afflicted suffer with pain at the base of the thumb which is aggravated by thumb use
Traditional surgical options can lead to significant hand strength loss or continued persistent pain
Difficulty doing everyday tasks such as turning a key or using a mobile telephone
Current implant devices associated with failure rates of up to 40%
The InDx implant is the only implant that can fully mimic the natural but complex motions of the thumb joint. The device is also easier to insert and less invasive than any currently available surgical treatment option for this condition.
The InDx device accommodates the full range of thumb joint motions by providing two points of rotation that can move both concurrently and independently of each other, while enabling the joint to move in at least six degrees of freedom. This will provide an excellent clinical outcome and decrease the risk of surgical and clinical complications.
The InDx device offers an exciting new, patient sensitive treatment option to patients and surgeons and has been designed in conjunction with three of the world’s leading hand surgeons ensuring all end-user requirements are met.
Based on our last pre-clinical studies, I really feel that the implant is now mature, and likely will be extremely successful.
Dr. Peter Weiss Brown UniversityThis implant would address the most tricky part of the current designs and offer a possibility to eliminate the principal cause of current joint failures
Prof. Filip Stockmans KU LeuvenLoci Orthopaedics and the InDx device originated from the BioInnovate program, a structured medical device innovation program in Ireland with proven outcomes. Loci Orthopaedics is based at the Business Innovation Centre in the National University of Ireland Galway.
Brendan graduated with honours from University College Dublin Medical School in 2006. As an undergraduate, he completed a Bachelor of Medical Science as a concurrent degree and was awarded the Colman Saunders medal for Paediatrics. As a post-graduate, he became a Member of the Royal College of Physicians of Ireland and also a member of the Irish College of General Practitioners. Brendan was a BioInnovate Ireland Fellow 2014 during which time he developed his skills in identifying and determining opportunities in the lifescience and health technology landscapes. He learned to critically appraise very early stage development opportunities and de-risk potential investment opportunities. He became adept at conducting in-depth industry, market and company research; due diligence, including assessing the competitive landscape; critical analysis of business opportunity assumptions using his extensive medical knowledge base; and evaluating industry trends.
Gerry has worked consistently in medical devices and diagnostics since the late 1970s, spending ten years in the USA industry sector during that time. He has had a number of increasingly responsible technical roles within Technicon, Sherwood Medical and C.R. Bard/Medtronic, most recently that of senior engineering manager within R&D at Medtronic. His expertise lies in process development, new technology investigation and product design methodologies. He has several patents and trade secrets to his credit and has been charged with IP development at leadership level. A believer in team synergy, he is passionate about innovation that occurs at the boundaries of diverse disciplines. Gerry was a BioInnovate Ireland Fellow 2014, during which he further developed his skills at identifying unmet clinical needs and finding solutions through the application of experience and good engineering practice.
John has over 30 years experience in the medical device industry and is one of the most experienced medical device leaders in Ireland. He ran Medtronic’s cardiovascular business in Galway for 15 years and was the founder and CEO of MedNova Ltd. MedNova pioneered embolic protection for endovascular treatment of carotid artery disease and gained worldwide approval for its products. John serves as Chairman of Vistamed Limited and Cambus Teoranta, and he served as Non-Executive Director of IDA Ireland from 1995 to 2000. He was a founder of Croi, the West of Ireland Cardiac Foundation, a voluntary organization to support the fight against heart disease and stroke. John was most recently co-founder and Chariman of Neuravi, a cerebral embolectomy company recently acquired by Johnson&Johnson Ltd.
Anton brings extensive experience in company development, product creation, commercialization and customer relationship management. Uniquely suited to Loci Orthopaedics mission, Anton’s experience of bringing a novel orthopedics product from concept, through US regulatory approval, and into a pivotal US-based clinical trial, will be directly applicable to our future here at Loci. His in-depth technical knowledge will complete an outstanding combination of clinical and commercial acumen that is directly applicable to Loci Orthopaedics. Anton is co-founder and CEO of MoxiMed, an orthopaedics medical device company. He has been a key member of the MoxiMed team that has brought a product from concept to clinical use.
Dr. Ladd is one of the world’s leading experts in the biomechanics and kinematics of the thumb base joint. She was a fellow at L'Institut de la Main in Paris, France prior to joining the Stanford University faculty in 1990
Dr. Weiss is an internationally recognised orthopaedic hand surgeon. He specialises in hand and wrist reconstruction with a special interest in finger and wrist joint replacement surgery.
Prof Stockmans has numerous peer-reviewed journal articles and book chapters on hand and thumb base joint surgery. He is one of the most prolific thumb base joint implant users in the world, with the best clinical outcomes recorded and studied of any European hand surgeon.
209 Business Innovation Centre,
National University of Ireland Galway,
Ireland